We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse.
- Authors
Arrieta, M C; Madsen, K; Doyle, J; Meddings, J
- Abstract
Defects in the small intestinal epithelial barrier have been associated with inflammatory bowel disease but their role in the causation of disease is still a matter of debate. In some models of disease increased permeability appears to be a very early event. The interleukin 10 (IL10) gene-deficient mouse spontaneously develops colitis after 12 weeks of age. These mice have been shown to have increased small intestinal permeability that appears early in life. Furthermore, the development of colitis is dependent upon luminal agents, as animals do not develop disease if raised under germ-free conditions.
- Publication
Gut, 2009, Vol 58, Issue 1, p41
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2008.150888