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- Title
Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes.
- Authors
Ahlén, G; Derk, E; Weiland, M; Jiao, J; Rahbin, N; Aleman, S; Peterson, D L; Pokrovskaja, K; Grandér, D; Frelin, L; Sällberg, M
- Abstract
Hepatitis C virus (HCV) effectively establishes persistent infection in human livers. The non-structural (NS) 3/4A complex participates in this process by cleavage of interferon beta (IFN beta) promoter stimulator-1 (IPS-1; also termed Cardif/MAVS/VISA), which inhibits responses to double stranded (ds) RNA. However, it is not known whether this effect extends beyond innate responses.
- Publication
Gut, 2009, Vol 58, Issue 4, p560
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2007.147264