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- Title
Genetically designing a more potent antipancreatic cancer agent by simultaneously co-targeting human IL13 and EGF receptors in a mouse xenograft model.
- Authors
Vallera, D A; Stish, B J; Shu, Y; Chen, H; Saluja, A; Buchsbaum, D J; Vickers, S M
- Abstract
Investigators are currently interested in the epidermal growth factor receptor (EGFR) and interleukin 13 receptor (IL13R) as potential targets in the development of new biologicals for pancreatic cancer. Attempts to develop successful agents have met with difficulty. The novel approach used here was to target these receptors simultaneously with EGF and IL13 cloned on the same bispecific single-chain molecule with truncated diphtheria toxin (DT(390)) to determine if co-targeting with DTEGF13 had any advantages.
- Publication
Gut, 2008, Vol 57, Issue 5, p634
- ISSN
1468-3288
- Publication type
Journal Article
- DOI
10.1136/gut.2007.137802