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- Title
Visceral pain perception is determined by the duration of colitis and associated neuropeptide expression in the mouse.
- Authors
Verma-Gandhu, Monica; Verdu, Elena F; Bercik, Premysl; Blennerhassett, Patricia A; Al-Mutawaly, Nafia; Ghia, Jean-Eric; Collins, Stephen M
- Abstract
Even though inflammation is a traditional tool for the induction of hyperalgesia in many tissues, recent observations suggest that not all inflammatory processes produce this change. Tolerance to colorectal distension (CRD) is reduced in patients with acute ulcerative colitis but is increased in patients with chronic inflammatory bowel disease. This suggests that the nature of the inflammatory infiltrate influences visceral perception.
- Publication
Gut, 2007, Vol 56, Issue 3, p358
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2006.100016