We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prion infectivity in variant Creutzfeldt-Jakob disease rectum.
- Authors
Wadsworth, J D F; Joiner, S; Fox, K; Linehan, J M; Desbruslais, M; Brandner, S; Asante, E A; Collinge, J
- Abstract
Disease-related prion protein (PrP(Sc)) is readily detectable in lymphoreticular tissues in variant Creutzfeldt-Jakob disease (vCJD), but not in other forms of human prion disease. This distinctive pathogenesis, with the unknown population prevalence of asymptomatic vCJD infection, has led to significant concerns that secondary transmission of vCJD prions will occur through a wide range of surgical procedures. To date PrP(Sc):prion infectivity ratios have not been determined in vCJD, and it is unknown whether vCJD prions are similar to experimental rodent prions, where PrP(Sc) concentration typically reflects infectious prion titre.
- Publication
Gut, 2007, Vol 56, Issue 1, p90
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2006.091637