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- Title
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2.
- Authors
Patsos, H A; Hicks, D J; Dobson, R R H; Greenhough, A; Woodman, N; Lane, J D; Williams, A C; Paraskeva, C
- Abstract
Cyclooxygenase 2 (COX-2) is upregulated in most colorectal cancers and is responsible for metabolism of the endogenous cannabinoid, anandamide, into prostaglandin-ethanolamides (PG-EAs). The aims of this study were to determine whether anandamide and PG-EAs induce cell death in colorectal carcinoma (CRC) cells, and whether high levels of COX-2 in CRC cells could be utilised for their specific targeting for cell death by anandamide.
- Publication
Gut, 2005, Vol 54, Issue 12, p1741
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2005.073403