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- Title
Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease.
- Authors
Dieterich, W; Esslinger, B; Trapp, D; Hahn, E; Huff, T; Seilmeier, W; Wieser, H; Schuppan, D
- Abstract
Intestinal inflammation in coeliac disease is driven by the gluten fraction of wheat proteins. Deamidation or cross linking of gluten peptides by tissue transglutaminase (tTG), the coeliac disease autoantigen, creates potent T cell stimulatory peptides. Therefore, our aim was to identify the reaction patterns of gluten peptides, intestinal extracellular matrix proteins, and tTG.
- Publication
Gut, 2006, Vol 55, Issue 4, p478
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2005.069385