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- Title
Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease.
- Authors
van Heel, D A; Ghosh, S; Hunt, K A; Mathew, C G; Forbes, A; Jewell, D P; Playford, R J
- Abstract
Nucleotide binding oligomerisation domain 2 (NOD2; also known as CARD15) mutations are associated with Crohn's disease but how mutations cause disease is poorly understood. Innate immune responses are reportedly enhanced by combined NOD2 ligand (muramyl dipeptide, MDP) and Toll-like receptor 4 ligand (TLR4, lipopolysaccharide) stimulation. Intestinal TLR signalling has a dual role-maintaining intestinal homeostasis and protection from injury as well as initiating inflammatory responses. TLR9 is functional in the intestinal epithelium where it is most strongly expressed in Paneth cells.
- Publication
Gut, 2005, Vol 54, Issue 11, p1553
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2005.065888