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Title
Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease.
Authors
Schreiter, K; Hausmann, M; Spoettl, T; Strauch, U G; Bataille, F; Schoelmerich, J; Herfarth, H; Falk, W; Rogler, G
Abstract
The glycoprotein (gp) 96 links the adaptive with the innate immune system. It is a chaperone with a binding domain for peptides generated by proteasomal degradation. During cellular stress, peptide loaded gp96 can be released and presented to T cells by antigen presenting cells (APCs).