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- Title
Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome.
- Authors
Morgan, V; Pickens, D; Gautam, S; Kessler, R; Mertz, H
- Abstract
Irritable bowel syndrome (IBS) is a disorder of intestinal hypersensitivity and altered motility, exacerbated by stress. Functional magnetic resonance imaging (fMRI) during painful rectal distension in IBS has demonstrated greater activation of the anterior cingulate cortex (ACC), an area relevant to pain and emotions. Tricyclic antidepressants are effective for IBS. The aim of this study was to determine if low dose amitriptyline reduces ACC activation during painful rectal distension in IBS to confer clinical benefits. Secondary aims were to identify other brain regions altered by amitriptyline, and to determine if reductions in cerebral activation are greater during mental stress.
- Publication
Gut, 2005, Vol 54, Issue 5, p601
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2004.047423