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- Title
Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.
- Authors
Abreu, M T; Kantorovich, V; Vasiliauskas, E A; Gruntmanis, U; Matuk, R; Daigle, K; Chen, S; Zehnder, D; Lin, Y-C; Yang, H; Hewison, M; Adams, J S
- Abstract
Many patients with Crohn's disease (CD) have low bone mineral density (BMD) that may not be solely attributable to glucocorticoid use. We hypothesised that low BMD in patients with CD is associated with elevated circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D). We further hypothesised that this was secondary to increased synthesis of 1,25(OH)(2)D by inflammatory cells in the intestine. The aim of this study was to examine the relationship between 1,25(OH)(2)D levels and BMD in patients with CD.
- Publication
Gut, 2004, Vol 53, Issue 8, p1129
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2003.036657