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- Title
NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression.
- Authors
Wehkamp, J; Harder, J; Weichenthal, M; Schwab, M; Schäffeler, E; Schlee, M; Herrlinger, K R; Stallmach, A; Noack, F; Fritz, P; Schröder, J M; Bevins, C L; Fellermann, K; Stange, E F
- Abstract
Mutations in NOD2, a putative intracellular receptor for bacterial peptidoglycans, are associated with a subset of Crohn's disease but the molecular mechanism linking this protein with the disease pathogenesis remains unclear. Human alpha defensins (HD-5 and HD-6) are antibiotic effector molecules predominantly expressed in Paneth cells of the ileum. Paneth cells also express NOD2. To address the hypothesis that the function of NOD2 may affect expression of Paneth cell defensins, we compared their expression levels with respect to NOD2 mutations in Crohn's disease.
- Publication
Gut, 2004, Vol 53, Issue 11, p1658
- ISSN
0017-5749
- Publication type
Journal Article
- DOI
10.1136/gut.2003.032805