We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A comparison of the analytical level of agreement of nine treponemal assays for syphilis and possible implications for screening algorithms.
- Authors
Jost, Heather; Castro, Arnold; Cox, David; Fakile, Yetunde; Kikkert, Susan; Tun, Ye; Zaidi, Akbar; Park, Mahin
- Abstract
The serological diagnosis of syphilis requires the detection of two distinct antibodies, the non-treponemal and trepomenal. Center for Disease Control and Prevention (CDC) recommends screening first with a non-treponemal test such as (Rapid Plasma Reagin/Venereal Disease Research Laboratory), and then confirming those results with one of the several treponemal tests (Fluorescent Treponemal Antibody-Absorption (FTA-ABS), Enzyme Immunoassay, chemiluminescence, treponema pallidum particle agglutination (TP-PA) or Point of Care). Owing to the high volume of samples processed by some laboratories using automated systems, the screening with treponemal assays and confirming with non-treponemal tests is becoming the established norm. The purpose of this study was to evaluate eight treponemal assays using TP-PA as the predicate assay.
- Publication
BMJ open, 2013, Vol 3, Issue 9, pe003347
- ISSN
2044-6055
- Publication type
Journal Article
- DOI
10.1136/bmjopen-2013-003347