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Title
Bias in meta-analysis detected by a simple, graphical test.
Authors
Egger, M; Davey Smith, G; Schneider, M; Minder, C
Abstract
Funnel plots (plots of effect estimates against sample size) may be useful to detect bias in meta-analyses that were later contradicted by large trials. We examined whether a simple test of asymmetry of funnel plots predicts discordance of results when meta-analyses are compared to large trials, and we assessed the prevalence of bias in published meta-analyses.
Publication
BMJ (Clinical research ed.), 1997, Vol 315, Issue 7109, p629