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- Title
3,4 dihydroxyphenyl ethanol reduces secretion of angiogenin in human retinal pigment epithelial cells.
- Authors
Granner, Tamara; Maloney, Shawn; Antecka, Emilia; Correa, José A; Burnier, Miguel N, Jr
- Abstract
Age-related macular degeneration (AMD) is currently the leading cause of blindness in developed countries. Bevacizumab is a widely used anti-VEGF agent that is a commonly applied therapy for neovascular AMD; however, a consequence of bevacizumab therapy may be the activation of compensatory angiogenic signalling. Combination of bevacizumab with 3,4 dihydroxyphenyl ethanol (DPE) may attenuate this compensatory signalling. The goal of the study was to investigate this therapeutic option in a human retinal pigment epithelial cell line (ARPE-19).
- Publication
The British journal of ophthalmology, 2013, Vol 97, Issue 3, p371
- ISSN
1468-2079
- Publication type
Journal Article
- DOI
10.1136/bjophthalmol-2012-302002