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- Title
A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy.
- Authors
Van Geest, Rob J; Lesnik-Oberstein, Sarit Y; Tan, H Stevie; Mura, Marco; Goldschmeding, Roel; Van Noorden, Cornelis J F; Klaassen, Ingeborg; Schlingemann, Reinier O
- Abstract
In proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) may cause blindness by neovascularisation followed by fibrosis of the retina. It has previously been shown that a shift in the balance between levels of CTGF and VEGF in the eye is associated with this angiofibrotic switch. This study investigated whether anti-VEGF agents induce accelerated fibrosis in patients with PDR, as predicted by this model.
- Publication
The British journal of ophthalmology, 2012, Vol 96, Issue 4, p587
- ISSN
1468-2079
- Publication type
Journal Article
- DOI
10.1136/bjophthalmol-2011-301005