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- Title
Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: a single masked trial.
- Authors
Ozyazgan, Y; Yurdakul, S; Yazici, H; Tüzün, B; Işçimen, A; Tüzün, Y; Aktunç, T; Pazarli, H; Hamuryudan, V; Müftüoğlu, A
- Abstract
A single masked trial of cyclosporin A 5 mg/kg/day versus monthly 1 g intravenous boluses of cyclophosphamide was conducted among 23 patients with Behçet's syndrome and active, potentially reversible uveitis. The trial was unmasked after a mean of 12 (SD 2) months for the cyclosporin A group (n = 12) and a mean of 10 (SD 3) months for the cyclophosphamide group (n = 11). During the initial 6 months the visual acuity significantly improved (p < 0.001) in the cyclosporin A group whereas this was not observed in the cyclophosphamide group. The subsequent follow-up of patients up to 24 months suggested that the initial improvement in visual acuity with cyclosporin A was not sustained. More extensive and especially long-term studies of cyclosporin A in the uveitis of Behçet's syndrome are warranted.
- Publication
The British journal of ophthalmology, 1992, Vol 76, Issue 4, p241
- ISSN
0007-1161
- Publication type
Journal Article
- DOI
10.1136/bjo.76.4.241