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- Title
Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis.
- Authors
Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard A; Morawietz, Lars; Kamradt, Thomas
- Abstract
Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ICOS/ICOSL interactions ameliorates G6PI-induced arthritis and reduces G6PI-specific B and T lymphocyte responses.
- Publication
Annals of the rheumatic diseases, 2010, Vol 69, Issue 8, p1495
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/ard.2009.119164