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- Title
Gene-environment interaction between HLA-DRB1 shared epitope and heavy cigarette smoking in predicting incident rheumatoid arthritis.
- Authors
Karlson, E W; Chang, S-C; Cui, J; Chibnik, L B; Fraser, P A; De Vivo, I; Costenbader, K H
- Abstract
Previous studies have reported an interaction between ever cigarette smoking and the presence of the human leukocyte antigen (HLA)-DRB1 shared epitope (SE) genotype and rheumatoid arthritis (RA) risk. To address the effect of dosage, a case-control study nested within two prospective cohorts to determine the interaction between heavy smoking and the HLA-SE was conducted.
- Publication
Annals of the rheumatic diseases, 2010, Vol 69, Issue 1, p54
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/ard.2008.102962