We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Contribution of Fcgamma receptor IIIA gene 158V/F polymorphism and copy number variation to the risk of ACPA-positive rheumatoid arthritis.
- Authors
Thabet, M M; Huizinga, T W J; Marques, R B; Stoeken-Rijsbergen, G; Bakker, A M; Kurreeman, F A; White, S J; Toes, R E M; van der Helm-van Mil, A H M
- Abstract
Fcgamma receptors (FcgammaRs) are potent immune modulators. FcgammaR genes encompass a complex region, polymorphic by both single nucleotide polymorphisms (SNPs) and copy number variation (CNV). The heterogeneity of rheumatoid arthritis (RA) combined with the genetic complexity of FcgammaR genes may be the cause of inconsistent findings in previous RA studies on FcgammaR SNPs. There is increasing evidence that anti-citrullinated peptide antibody (ACPA)-positive RA and ACPA-negative RA have a different genetic background.
- Publication
Annals of the rheumatic diseases, 2009, Vol 68, Issue 11, p1775
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/ard.2008.099309