We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus.
- Authors
Sawalha, A H; Kaufman, K M; Kelly, J A; Adler, A J; Aberle, T; Kilpatrick, J; Wakeland, E K; Li, Q-Z; Wandstrat, A E; Karp, D R; James, J A; Merrill, J T; Lipsky, P; Harley, J B
- Abstract
The aetiology of systemic lupus erythematosus (SLE) is incompletely understood. Both genetic and environmental factors are implicated in the pathogenesis of the disease. Herein, we describe genetic association between SLE and polymorphisms in the interleukin (IL)-21 gene. The reported effect of IL-21 on B-cell differentiation into plasma cells and its effect on dendritic cell maturation and T-cell responses make IL-21 an attractive candidate gene for SLE.
- Publication
Annals of the rheumatic diseases, 2008, Vol 67, Issue 4, p458
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/ard.2007.075424