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- Title
The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis.
- Authors
Harnett, M M; Kean, D E; Boitelle, A; McGuiness, S; Thalhamer, T; Steiger, C N; Egan, C; Al-Riyami, L; Alcocer, M J; Houston, K M; Gracie, J A; McInnes, I B; Harnett, W
- Abstract
In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demonstrated that ES-62, a 62 kDa phosphorylcholine (PC)-containing glycoprotein that is secreted by filarial nematodes, can exert anti-inflammatory action in the murine collagen-induced arthritis (CIA) model and human rheumatoid arthritis-derived synovial tissue cultures. As a first step to developing ES-62-based drugs, the aim of this study was to determine whether the PC-moiety of ES-62 was responsible for its anti-inflammatory actions.
- Publication
Annals of the rheumatic diseases, 2008, Vol 67, Issue 4, p518
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/ard.2007.073502