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- Title
Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis.
- Authors
Faber, C; Morbach, H; Singh, S K; Girschick, H J
- Abstract
Re-expression of the recombination-activating genes (RAG) in peripheral B cells may be relevant in the development of autoreactive antibodies in autoimmune diseases. The presence of antinuclear antibodies (ANA) as a hallmark of oligoarticular juvenile idiopathic arthritis (o-JIA, early-onset type) indicates a breakdown in immunological tolerance.
- Publication
Annals of the rheumatic diseases, 2006, Vol 65, Issue 10, p1351
- ISSN
0003-4967
- Publication type
Journal Article
- DOI
10.1136/ard.2005.047878