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- Title
Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis.
- Authors
Noponen-Hietala, N; Kyllönen, E; Männikkö, M; Ilkko, E; Karppinen, J; Ott, J; Ala-Kokko, L
- Abstract
Degenerative lumbar spinal stenosis (LSS) is usually caused by disc herniation or degeneration. Several genetic factors have been implicated in disc disease. Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. In addition, an IVS6-4 a>t polymorphism in COL11A2 has been found in connection with stenosis caused by ossification of the posterior longitudinal ligament in the Japanese population.
- Publication
Annals of the rheumatic diseases, 2003, Vol 62, Issue 12, p1208
- ISSN
0003-4967
- Publication type
Journal Article
- DOI
10.1136/ard.2003.008334