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- Title
The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis.
- Authors
Dees, Clara; Schlottmann, Inga; Funke, Robin; Distler, Alfiya; Palumbo-Zerr, Katrin; Zerr, Pawel; Lin, Neng-Yu; Beyer, Christian; Distler, Oliver; Schett, Georg; Distler, Jörg H W
- Abstract
Activated Wnt signalling with decreased expression of endogenous inhibitors has recently been characterised as a central pathomechanism in systemic sclerosis (SSc). Aberrant epigenetic modifications also contribute to the persistent activation of SSc fibroblasts. We investigated whether increased Wnt signalling and epigenetic changes in SSc are causally linked via promoter hypermethylation-induced silencing of Wnt antagonists.
- Publication
Annals of the rheumatic diseases, 2014, Vol 73, Issue 6, p1232
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/annrheumdis-2012-203194