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- Title
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
- Authors
Quirke, Anne-Marie; Lugli, Elena Birgitta; Wegner, Natalia; Hamilton, Bart C; Charles, Peter; Chowdhury, Muslima; Ytterberg, A Jimmy; Zubarev, Roman A; Potempa, Jan; Culshaw, Shauna; Guo, Yonghua; Fisher, Benjamin A; Thiele, Geoffrey; Mikuls, Ted R; Venables, Patrick Jw
- Abstract
Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis to RA. P gingivalis is apparently unique among periodontal pathogens in possessing a citrullinating enzyme, peptidylarginine deiminase (PPAD) with the potential to generate antigens driving the autoimmune response.
- Publication
Annals of the rheumatic diseases, 2014, Vol 73, Issue 1, p263
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/annrheumdis-2012-202726