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- Title
Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study.
- Authors
Clockaerts, S; Van Osch, G J V M; Bastiaansen-Jenniskens, Y M; Verhaar, J A N; Van Glabbeek, F; Van Meurs, J B; Kerkhof, H J M; Hofman, A; Stricker, B H Ch; Bierma-Zeinstra, S M
- Abstract
Osteoarthritis is the most frequent chronic joint disease causing pain and disability. Besides biomechanical mechanisms, the pathogenesis of osteoarthritis may involve inflammation, vascular alterations and dysregulation of lipid metabolism. As statins are able to modulate many of these processes, this study examines whether statin use is associated with a decreased incidence and/or progression of osteoarthritis.
- Publication
Annals of the rheumatic diseases, 2012, Vol 71, Issue 5, p642
- ISSN
1468-2060
- Publication type
Journal Article
- DOI
10.1136/annrheumdis-2011-200092