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- Title
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
- Authors
McFarland, R; Hudson, G; Taylor, R W; Green, S H; Hodges, S; McKiernan, P J; Chinnery, P F; Ramesh, V
- Abstract
We report the case of a 2-year-old boy with seizures who developed hepatic failure shortly after commencing sodium valproate. Unexpectedly, liver function returned to normal on stopping the drug. Sequencing of the mitochondrial polymerase gamma gene (POLG1) revealed four heterozygous substitutions, two of which have been identified in cases of Alpers-Huttenlocher disease.
- Publication
Archives of disease in childhood, 2008, Vol 93, Issue 2, p151
- ISSN
1468-2044
- Publication type
Journal Article
- DOI
10.1136/adc.2007.122911