Title

Synthesis of pyrimidinocyclophanes having a bridging nitrogen atom.

Authors

Semenov, V. E.; Nikolaev, A. E.; Kozlov, A. V.; Efremov, Yu. Ya.; Latypov, Sh. K.; Reznik, V. S.

Abstract

Reactions of 1,3-bis(ω-bromoalkyl)-substituted uracils, quinazoline-2,4-dione, and 5-methyl-1,3,5-triazine-2,4,6-trione and 1,3-bis( m-bromomethylbenzyl)-5-bromouracil with amines (aliphatic amines, benzylamines, naphthylmethanamine, and anisidine) gave a series of macrocyclic compounds having one pyrimidine or triazine fragment and an azapolymethylene bridge connecting the N1 and N3 atoms of the heteroring. The bridging nitrogen atom in some macrocyclic compounds was subjected to quaternization with methyl p-toluenesulfonate.

Subjects

NITROGEN; CHEMICAL reactions; URACIL; TRIAZINES; ORGANIC compounds; MACROCYCLIC compounds

Publication

Russian Journal of Organic Chemistry, 2008, Vol 44, Issue 6, p882

ISSN

1070-4280

Publication type

Academic Journal

DOI

10.1134/S1070428008060183