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Title: Synthesis and biological activity of new hybrids compounds derived from benzofuroxanes and polyene antibiotics.
Authors: Chugunova, E.; Mukhamatdinova, R.; Sazykina, M.; Sazykin, I.; Khammami, M.; Akylbekov, N.; Burilov, A.; Kulik, N.; Zobov, V.
Abstract: Hybrid compounds based on 4,6-dichloro-5-nitrobenzofuroxan, 7-chloro-4,6-dinitrobenzofuroxan, 5,7-dichloro-4,6-dinitrobenzofuroxan, and polyene antibiotics (amphotericin B and nystatin) have been prepared for the first time. They have exhibited biological activity comparable to that of starting antibiotics. Activity of the compound derived from 5,7-dichloro-4,6-dinitrobenzofuroxan and nystatin towards Trichophyton mentagrophytes is 4 times higher than that of nystatin.
Subjects: POLYENE antibiotics; FURAZANS; AMPHOTERICIN B; NYSTATIN; TRICHOPHYTON
Publication: Russian Journal of General Chemistry, 2016, Vol 86, Issue 5, p1037
ISSN: 1070-3632
Publication type: Academic Journal
DOI: 10.1134/S1070363216050091

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Synthesis and biological activity of new hybrids compounds derived from benzofuroxanes and polyene antibiotics.