Title

Condensation of thiourea with uracyl derivatives containing ketone and ketoester fragments, alkylation and macrocyclization of the condensation products.

Authors

Krylova, E. S.; Semenov, V. E.; Akamsin, V. D.; Reznik, V. S.

Abstract

By condensation of thiourea with 6-methyluracyl derivatives containing ketone and ketoester fragmenst in the alkyl chains attached to the nitrogen atoms of the pyrimidine ring the products containing 6-methyl- or 3,6-dimethyluracyl fragment and one or two 6-methyl-4-oxo-2-thio-1,2,3,4-tetrahydropyrimidin-5-yl fragments were synthesized. These compounds can be alkylated with alkyl bromides.

Subjects

CONDENSATION; THIOUREA; KETONES; ALKYLATION; BROMIDES

Publication

Russian Journal of General Chemistry, 2010, Vol 80, Issue 7, p1364

ISSN

1070-3632

Publication type

Academic Journal

DOI

10.1134/S107036321007025X