Title

Quinone-dependent alcohol dehydrogenases and fad-dependent alcohol oxidases.

Authors

Gvozdev, A.; Tukhvatullin, I.; Gvozdev, R.

Abstract

This review considers quinone-dependent alcohol dehydrogenases and FAD-dependent alcohol oxidases, enzymes that are present in numerous methylotrophic eu- and prokaryotes and significantly differ in their primary and quaternary structure. The cofactors of the enzymes are bound to the protein polypeptide chain through ionic and hydrophobic interactions. Microorganisms containing these enzymes are described. Methods for purification of the enzymes, their physicochemical properties, and spatial structures are considered. The supposed mechanism of action and practical application of these enzymes as well as their producers are discussed.

Subjects

ALCOHOL dehydrogenase; QUINONE; ALCOHOL oxidase; PROKARYOTES; POLYPEPTIDES; METHANOL dehydrogenase; HEMOPROTEINS; BIOCHEMICAL mechanism of action

Publication

Biochemistry (00062979), 2012, Vol 77, Issue 8, p843

ISSN

0006-2979

Publication type

Academic Journal

DOI

10.1134/S0006297912080056