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- Title
Connecting chromosomes, crisis, and cancer.
- Authors
Maser, Richard S; DePinho, Ronald A
- Abstract
Cancer is a disease of impaired genome stability. The molecular forces that maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer cells. Here, we explore the contrasting contributions of telomeres in the initiation and suppression of cancer and review the evidence supporting a role for telomere dysfunction as a mechanism driving the radical chromosomal aberrations that typify cancer genomes. Recent work suggests that passage of cells through crisis in the setting of deactivated DNA damage checkpoints provides a mutational mechanism that can generate the diverse genetic alterations required for cancer initiation. A greater understanding of telomere-induced crisis and the cell's crisis management mechanisms should guide the rational development of new therapeutics for cancer and other disorders.
- Publication
Science (New York, N.Y.), 2002, Vol 297, Issue 5581, p565
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.297.5581.565