We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The phosphoinositide 3-kinase pathway.
- Authors
Cantley, Lewis C
- Abstract
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
- Publication
Science (New York, N.Y.), 2002, Vol 296, Issue 5573, p1655
- ISSN
1095-9203
- Publication type
Journal Article
- DOI
10.1126/science.296.5573.1655