We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Nuclear receptors and lipid physiology: opening the X-files.
- Authors
Chawla, A; Repa, J J; Evans, R M; Mangelsdorf, D J
- Abstract
Cholesterol, fatty acids, fat-soluble vitamins, and other lipids present in our diets are not only nutritionally important but serve as precursors for ligands that bind to receptors in the nucleus. To become biologically active, these lipids must first be absorbed by the intestine and transformed by metabolic enzymes before they are delivered to their sites of action in the body. Ultimately, the lipids must be eliminated to maintain a normal physiological state. The need to coordinate this entire lipid-based metabolic signaling cascade raises important questions regarding the mechanisms that govern these pathways. Specifically, what is the nature of communication between these bioactive lipids and their receptors, binding proteins, transporters, and metabolizing enzymes that links them physiologically and speaks to a higher level of metabolic control? Some general principles that govern the actions of this class of bioactive lipids and their nuclear receptors are considered here, and the scheme that emerges reveals a complex molecular script at work.
- Publication
Science (New York, N.Y.), 2001, Vol 294, Issue 5548, p1866
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.294.5548.1866