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- Title
Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice.
- Authors
Nishimura, H; Okazaki, T; Tanaka, Y; Nakatani, K; Hara, M; Matsumori, A; Sasayama, S; Mizoguchi, A; Hiai, H; Minato, N; Honjo, T
- Abstract
Dilated cardiomyopathy is a severe pathology of the heart with poorly understood etiology. Disruption of the gene encoding the negative immunoregulatory receptor PD-1 in BALB/c mice, but not in BALB/c RAG-2-/- mice, caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure. Affected hearts showed diffuse deposition of immunoglobulin G (IgG) on the surface of cardiomyocytes. All of the affected PD-1-/- mice exhibited high-titer circulating IgG autoantibodies reactive to a 33-kilodalton protein expressed specifically on the surface of cardiomyocytes. These results indicate that PD-1 may be an important factor contributing to the prevention of autoimmune diseases.
- Publication
Science (New York, N.Y.), 2001, Vol 291, Issue 5502, p319
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.291.5502.319