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- Title
Extended life-span conferred by cotransporter gene mutations in Drosophila.
- Authors
Rogina, B; Reenan, R A; Nilsen, S P; Helfand, S L
- Abstract
Aging is genetically determined and environmentally modulated. In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity. Sequence analysis revealed that the product of this gene, named Indy (for I'm not dead yet), is most closely related to a mammalian sodium dicarboxylate cotransporter-a membrane protein that transports Krebs cycle intermediates. Indy was most abundantly expressed in the fat body, midgut, and oenocytes: the principal sites of intermediary metabolism in the fly. Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5499, p2137
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5499.2137