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- Title
Orchestrated transcription of key pathways in Arabidopsis by the circadian clock.
- Authors
Harmer, S L; Hogenesch, J B; Straume, M; Chang, H S; Han, B; Zhu, T; Wang, X; Kreps, J A; Kay, S A
- Abstract
Like most organisms, plants have endogenous biological clocks that coordinate internal events with the external environment. We used high-density oligonucleotide microarrays to examine gene expression in Arabidopsis and found that 6% of the more than 8000 genes on the array exhibited circadian changes in steady-state messenger RNA levels. Clusters of circadian-regulated genes were found in pathways involved in plant responses to light and other key metabolic pathways. Computational analysis of cycling genes allowed the identification of a highly conserved promoter motif that we found to be required for circadian control of gene expression. Our study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5499, p2110
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5499.2110