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- Title
Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow.
- Authors
Mezey, E; Chandross, K J; Harta, G; Maki, R A; McKercher, S R
- Abstract
Bone marrow stem cells give rise to a variety of hematopoietic lineages and repopulate the blood throughout adult life. We show that, in a strain of mice incapable of developing cells of the myeloid and lymphoid lineages, transplanted adult bone marrow cells migrated into the brain and differentiated into cells that expressed neuron-specific antigens. These findings raise the possibility that bone marrow-derived cells may provide an alternative source of neurons in patients with neurodegenerative diseases or central nervous system injury.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5497, p1779
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5497.1779