We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system.
- Authors
Schöning, K; Scholz, P; Guntha, S; Wu, X; Krishnamurthy, R; Eschenmoser, A
- Abstract
TNAs [(L)-alpha-threofuranosyl oligonucleotides] containing vicinally connected (3'-->2') phosphodiester bridges undergo informational base pairing in antiparallel strand orientation and are capable of cross-pairing with RNA and DNA. Being derived from a sugar containing only four carbons, TNA is structurally the simplest of all potentially natural oligonucleotide-type nucleic acid alternatives studied thus far. This, along with the base-pairing properties of TNA, warrants close scrutiny of the system in the context of the problem of RNA's origin.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5495, p1347
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5495.1347