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- Title
Direct coupling between meiotic DNA replication and recombination initiation.
- Authors
Borde, V; Goldman, A S; Lichten, M
- Abstract
During meiosis in Saccharomyces cerevisiae, DNA replication occurs 1. 5 to 2 hours before recombination initiates by DNA double-strand break formation. We show that replication and recombination initiation are directly linked. Blocking meiotic replication prevented double-strand break formation in a replication-checkpoint-independent manner, and delaying replication of a chromosome segment specifically delayed break formation in that segment. Consequently, the time between replication and break formation was held constant in all regions. We suggest that double-strand break formation occurs as part of a process initiated by DNA replication, which thus determines when meiotic recombination initiates on a regional rather than a cell-wide basis.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5492, p806
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5492.806