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- Title
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.
- Authors
Yan, M; Wang, L C; Hymowitz, S G; Schilbach, S; Lee, J; Goddard, A; de Vos, A M; Gao, W Q; Dixit, V M
- Abstract
Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR). In situ binding and organ culture studies indicate that EDA-A1 and EDA-A2 are differentially expressed and play a role in epidermal morphogenesis.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5491, p523
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5491.523