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- Title
A myosin I isoform in the nucleus.
- Authors
Pestic-Dragovich, L; Stojiljkovic, L; Philimonenko, A A; Nowak, G; Ke, Y; Settlage, R E; Shabanowitz, J; Hunt, D F; Hozak, P; de Lanerolle, P
- Abstract
A nuclear isoform of myosin I beta that contains a unique 16-amino acid amino-terminal extension has been identified. An affinity-purified antibody to the 16-amino acid peptide demonstrated nuclear staining. Confocal and electron microscopy revealed that nuclear myosin I beta colocalized with RNA polymerase II in an alpha-amanitin- and actinomycin D-sensitive manner. The antibody coimmunoprecipitated RNA polymerase II and blocked in vitro RNA synthesis. This isoform of myosin I beta appears to be in a complex with RNA polymerase II and may affect transcription.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5490, p337
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5490.337