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- Title
Molecular and neuronal substrate for the selective attenuation of anxiety.
- Authors
Löw, K; Crestani, F; Keist, R; Benke, D; Brünig, I; Benson, J A; Fritschy, J M; Rülicke, T; Bluethmann, H; Möhler, H; Rudolph, U
- Abstract
Benzodiazepine tranquilizers are used in the treatment of anxiety disorders. To identify the molecular and neuronal target mediating the anxiolytic action of benzodiazepines, we generated and analyzed two mouse lines in which the alpha2 or alpha3 GABAA (gamma-aminobutyric acid type A) receptors, respectively, were rendered insensitive to diazepam by a knock-in point mutation. The anxiolytic action of diazepam was absent in mice with the alpha2(H101R) point mutation but present in mice with the alpha3(H126R) point mutation. These findings indicate that the anxiolytic effect of benzodiazepine drugs is mediated by alpha2 GABAA receptors, which are largely expressed in the limbic system, but not by alpha3 GABAA receptors, which predominate in the reticular activating system.
- Publication
Science (New York, N.Y.), 2000, Vol 290, Issue 5489, p131
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.290.5489.131