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- Title
PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected].
- Authors
Kroll, T G; Sarraf, P; Pecciarini, L; Chen, C J; Mueller, E; Spiegelman, B M; Fletcher, J A
- Abstract
Chromosomal translocations that encode fusion oncoproteins have been observed consistently in leukemias/lymphomas and sarcomas but not in carcinomas, the most common human cancers. Here, we report that t(2;3)(q13;p25), a translocation identified in a subset of human thyroid follicular carcinomas, results in fusion of the DNA binding domains of the thyroid transcription factor PAX8 to domains A to F of the peroxisome proliferator-activated receptor (PPAR) gamma1. PAX8-PPARgamma1 mRNA and protein were detected in 5 of 8 thyroid follicular carcinomas but not in 20 follicular adenomas, 10 papillary carcinomas, or 10 multinodular hyperplasias. PAX8-PPARgamma1 inhibited thiazolidinedione-induced transactivation by PPARgamma1 in a dominant negative manner. The experiments demonstrate an oncogenic role for PPARgamma and suggest that PAX8-PPARgamma1 may be useful in the diagnosis and treatment of thyroid carcinoma.
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5483, p1357
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5483.1357