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- Title
Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.
- Authors
Li, H; Kolluri, S K; Gu, J; Dawson, M I; Cao, X; Hobbs, P D; Lin, B; Chen, G; Lu, J; Lin, F; Xie, Z; Fontana, J A; Reed, J C; Zhang, X
- Abstract
TR3, an immediate-early response gene and an orphan member of the steroid-thyroid hormone-retinoid receptor superfamily of transcription factors, regulates apoptosis through an unknown mechanism. In response to apoptotic stimuli, TR3 translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis. Mitochondrial targeting of TR3, but not its DNA binding and transactivation, is essential for its proapoptotic effect. Our results reveal a mechanism by which a nuclear transcription factor translocates to mitochondria to initiate apoptosis.
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5482, p1159
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5482.1159