We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Apoptosis. Mitochondria--the death signal integrators.
- Authors
Brenner, C; Kroemer, G
- Abstract
Many of the intricate pathways of apoptosis that instruct a cell to kill itself involve the convergence of key proteins on the membranes of mitochondria. Such proteins induce the permeabilization of mitochondrial membranes and the release of caspase enzymes and nuclease activators that set in motion the final stages of programmed cell death. Now, as Brenner and Kroemer discuss in their Perspective, a proapoptotic transcription factor called TR3 has been found to move from its normal location in the nucleus to the mitochondria and to promote release of cytochrome c, a key event in apoptosis (Li et al.)
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5482, p1150
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5482.1150