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- Title
Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter.
- Authors
Bellocchio, E E; Reimer, R J; Fremeau, R T, Jr; Edwards, R H
- Abstract
Previous work has identified two families of proteins that transport classical neurotransmitters into synaptic vesicles, but the protein responsible for vesicular transport of the principal excitatory transmitter glutamate has remained unknown. We demonstrate that a protein that is unrelated to any known neurotransmitter transporters and that was previously suggested to mediate the Na(+)-dependent uptake of inorganic phosphate across the plasma membrane transports glutamate into synaptic vesicles. In addition, we show that this vesicular glutamate transporter, VGLUT1, exhibits a conductance for chloride that is blocked by glutamate.
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5481, p957
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5481.957