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- Title
Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis.
- Authors
Shonn, M A; McCarroll, R; Murray, A W
- Abstract
The spindle checkpoint was characterized in meiosis of budding yeast. In the absence of the checkpoint, the frequency of meiosis I missegregation increased with increasing chromosome length, reaching 19% for the longest chromosome. Meiosis I nondisjunction in spindle checkpoint mutants could be prevented by delaying the onset of anaphase. In a recombination-defective mutant (spo11Delta), the checkpoint delays the biochemical events of anaphase I, suggesting that chromosomes that are attached to microtubules but are not under tension can activate the spindle checkpoint. Spindle checkpoint mutants reduce the accuracy of chromosome segregation in meiosis I much more than that in meiosis II, suggesting that checkpoint defects may contribute to Down syndrome.
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5477, p300
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5477.300