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- Title
Role of the mouse ank gene in control of tissue calcification and arthritis.
- Authors
Ho, A M; Johnson, M D; Kingsley, D M
- Abstract
Mutation at the mouse progressive ankylosis (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. Here, we show that the ank locus encodes a multipass transmembrane protein (ANK) that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. A highly conserved gene is present in humans and other vertebrates. These results identify ANK-mediated control of pyrophosphate levels as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
- Publication
Science (New York, N.Y.), 2000, Vol 289, Issue 5477, p265
- ISSN
0036-8075
- Publication type
Journal Article
- DOI
10.1126/science.289.5477.265